Although lamotrigine has some protective effects, it tends to lower the metabolic rate in various parts of the brain: an effect that may relate to its ability to promote atrophic neurodegeneration (or the breakdown of brain tissue) in the developing brain:
“After lamotrigine administration, cerebral metabolism was decreased in bilateral thalami, bilateral caudate nuclei, the left side of the putamen, the left entorhinal area, bilateral parahippocampal gyri, the right inferior temporal gyrus, the left rectosubcallosal gyrus, bilateral superior frontal gyri, the left middle frontal gyrus, the right precentral gyrus, left pericentral gyri, the right superior parietal lobule, and bilateral substantia nigra at P<.05 corrected for multiple comparisons using the false discovery rate approach. No brain region showed increased metabolism after lamotrigine administration.”
Reference: https://www.ncbi.nlm.nih.gov/pubmed/16966506
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