Q&A: DHEA Increases Dopamine and Testosterone

Q: “My sex drive is still hit and miss, as is my sense of pleasure, euphoria, social cleverness, wit (basically everything associated with dopaminergic activity and high testosterone.)  As shown by my crystal clear vision (as opposed to my previous myopia), serotonin seems quite low, so I believe I’m getting the best ‘bang for my buck,’ in regards to what testosterone and dopamine that I do possess.  I’ve been doing NoFap to further lower prolactin and serotonin, but are there any other methods that you have found to raise dopamine and testosterone, aside from anabolic steroids of course?  I’m trying to get a sky-high sex drive and more wit in conversation, which definitely happens when I initially took caffeine, so it definitely is dopamine.”

A (by Georgi Dinkov): Taking as little as 5mg DHEA, and up to 15mg per day in divided doses usually does wonders for sex drive.  DHEA also stimulated oxidative metabolism in the brain so it should increase dopamine.  DHEA also inhibits TPH, which is the enzyme that produces serotonin.  So, try it out and let me know how it goes.  Most people that tried it swear by DHEA for libido and overall energy.

DHEA should raise libido even in an 18 old, without causing hormonal axis shutdown due to elevated serum levels.

Date: 9/15/2015

Cold Weather Wrecks Your Thyroid

Researchers examined the effects of temperature and food intake on thyroid function in 4-week-old pigs over a period 6 weeks:

“The separate effects of ambient temperature and energy intake on the metabolism of thyroid hormones in the young pig have been investigated. Piglets were kept singly from 4 weeks of age at 10 or 35 degrees C on a high (H), or low (L) energy intake, such that H = 2L.”

They measured their thyroid hormones 16-21 hours after their last meal when the pigs reached 10 weeks old:

“At the tenth week of age blood samples were taken 16-21 h after the last meal for the determination of plasma concentrations of thyroxine (T4) and 3,5,3′-triiodothyronine (T3).”

They then measured the fractional disappearance rate of thyroid hormones, which shows represents how fast the body destroys its thyroid hormone, for example in extreme stress:

“At the end of the tenth week of age the fractional disappearance rate (K) of T4 was determined and finally the K value for T3 was estimated.”

They found that a high food intake increased the pigs’ production of thyroid hormones:

“Plasma concentrations of T4 and T3 were greater in animals on a high intake than in those on a low intake, (P less than 0.02), but the temperature at which the animals lived had no significant effect.”

Pigs destroyed their own thyroid hormones faster in cold temperatures:

“The values of K for T4 and T3 were greater at 10 than at 35 degrees C (P less than 0.010 and P less than 0.05), and energy intake had no significant effect.”

Cold temperatures and high caloric intakes significantly increased their needs for thyroid hormone:

“Calculations of the catabolic rates in nmol/kg X h revealed that for T4 the rate was greater at 10 than at 35 degrees C (P less than 0.001) and on a high than on a low intake (P less than 0.01).  Similar differences were found between the mean values of T3 with respect to both temperature and energy intake, but the variance was large and they did not reach statistical significance.  It is concluded that the metabolism of thyroid hormones is influenced independently by both ambient temperature and energy intake.”

References

Macari, M., Dauncey, M. J., Ramsden, D. B., & Ingram, D. L. (1983). Thyroid hormone metabolism after acclimatization to warm or cold temperature under conditions of high or low energy intake. Quarterly Journal of Experimental Physiology (Cambridge, England), 68(4), 709–718. The separate effects of ambient temperature and energy intake on the metabolism of thyroid hormones in the young pig have been investigated. Piglets were kept singly from 4 weeks of age at 10 or 35 degrees C on a high (H), or low (L) energy intake, such that H = 2L. At the tenth week of age blood samples were taken 16-21 h after the last meal for the determination of plasma concentrations of thyroxine (T4) and 3,5,3’-triiodothyronine (T3). At the end of the tenth week of age the fractional disappearance rate (K) of T4 was determined and finally the K value for T3 was estimated. Plasma concentrations of T4 and T3 were greater in animals on a high intake than in those on a low intake, (P less than 0.02), but the temperature at which the animals lived had no significant effect. The values of K for T4 and T3 were greater at 10 than at 35 degrees C (P less than 0.010 and P less than 0.05), and energy intake had no significant effect. Calculations of the catabolic rates in nmol/kg X h revealed that for T4 the rate was greater at 10 than at 35 degrees C (P less than 0.001) and on a high than on a low intake (P less than 0.01). Similar differences were found between the mean values of T3 with respect to both temperature and energy intake, but the variance was large and they did not reach statistical significance. It is concluded that the metabolism of thyroid hormones is influenced independently by both ambient temperature and energy intake.